Psoriasis
Psoriasis is a chronic autoimmune condition producing thick, scaly plaques. It affects roughly 3% of U.S. adults and is associated with psoriatic arthritis and cardiovascular disease.
Symptoms
Well-demarcated, raised, red plaques with silvery-white scale on elbows, knees, scalp, and lower back. Nail pitting occurs in up to half of patients. Joint pain suggests psoriatic arthritis.
Causes and risk
Overactive T-cell -- mediated immune response drives rapid keratinocyte proliferation. Triggers include strep throat, stress, smoking, obesity, and certain medications.
How it is evaluated
Diagnosis is usually clinical. Biopsy confirms uncertain cases. We calculate body surface area and screen for psoriatic arthritis, metabolic syndrome, and depression.
Treatment
Mild disease uses topical corticosteroids and vitamin D analogues. Moderate-to-severe psoriasis may require phototherapy, methotrexate, or biologics targeting TNF-alpha, IL-17, or IL-23. Our Chicago providers develop step-up plans.